Selective IgM Deficiency—An Underestimated Primary Immunodeficiency
نویسندگان
چکیده
منابع مشابه
Selective IgM Deficiency—An Underestimated Primary Immunodeficiency
Although selective IgM deficiency (SIGMD) was described almost five decades ago, it was largely ignored as a primary immunodeficiency. SIGMD is defined as serum IgM levels below two SD of mean with normal serum IgG and IgA. It appears to be more common than originally realized. SIGMD is observed in both children and adults. Patients with SIGMD may be asymptomatic; however, approximately 80% of ...
متن کاملPediatric Selective IgM Immunodeficiency
OBJECTIVE Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID). Previously published pediatric cases and 2 new cases are reviewed. METHODS English literature from PubMed and references from relevant articles were reviewed. Previously reported cases and 2 new cases from an allergy/immunology practice were analyzed. RESULTS Forty-nine reported cases of S...
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Selective immunoglobulin M deficiency(sIgMD) is a rare form of dysgammaglobulinaemia characterized by an isolated low level of serum immunoglobulin M (IgM). It was an incidence of less than 0.03% in the general population and 1% in hospitalized patients. sIgMD may occur as a primary or secondary condition. sIgMD is much more common than primary .Hemophagocytic lymphohistiocytosis (HLH) is also ...
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[1] Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ. Status of childhood asthma in the United States, 1980e2007. Pediatrics. 2009;123(suppl 3):S131eS245. [2] Merrill CT, Owens PL. Reasons for Being Admitted to the Hospital through the Emergency Department for Children and Adolescents, 2004. HCUP Statistical Brief 33. Rockville, MD: Agency for Healthcare Research and Quality, http://www. hcupus.ahr...
متن کاملSevere selective IgM deficiency.
Among the primary antibody deficiency syndromes, severe selective IgM deficiency (also previously known as type V dysgammaglobulinaemia) is rare, and the majority of previous reports have indicated a fatal outcome. Three adult patients who were found to have a persistently low serum IgM are described. This deficiency was not obviously related to their presenting illness; in two of the patients,...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2017
ISSN: 1664-3224
DOI: 10.3389/fimmu.2017.01056